Session Five - Poster Session A including Refreshments — ASN Events

Session Five - Poster Session A including Refreshments — ASN Events

Session Five - Poster Session A including Refreshments

Proudly sponsored by LCPSF

Identification of kinases upstream of AMPK regulatory site β1 Serine108 (#101)

Investigating pathways associated with glycogen breakdown and glutamate re-uptake in astrocytes following stroke and Rho-kinase inhibition (#102)

Src protein tyrosine kinase is critical for neuronal cell survival and demise (#104)

Md Ashfaqul Hoque

Structural characterisation of pREX1 activity in cancer cell signalling (#105)

Christina MA Lucato

Computational modelling of representative human bile (#106)

Novel Pyridazinone Inhibitors for Vascular Adhesion Protein-1 (VAP-1): Old Target – New Inhibition Mode (#107)

Eva Bligt-Linden

Investigating Regulators of the Leucine Rich-Repeat Kinase 2 (LRRK2) (#108)

Functional characterisation of Ab-WbjB, an extended short-chain dehydrogenase/reductase found in the multidrug-resistant bacteria Acinetobacter baumannii. (#109)

Structure-based design of folate-pathway inhibitors (#110)

Matthew L Dennis

Crystal structures of Mycobacterium tuberculosis hypoxanthine-guanine phosphoribosyltransferase: A new therapeutic drug target (#111)

Acetohydroxyacid synthase inhibitors as chemotherapeutic agents for pathogenic invasive fungal infections (#112)

Exploring the role of a dynamic accessory domain (#113)

Disulfide Hand-Off Captured by Single-Molecule Enzymology (#114)

HisZ: Friend or Foe? (#115)

Emma Livingstone

Sorting Sortase Substrates - Exploring the bioconjugation capabilities of Staphylococcus aureus transpeptidase sortase A (#116)

Matthias Nachtschatt

TARGETTING THE FASII REDUCTASES OF NEISSERIA GONORRHOAEA AS NOVEL TREATMENT OPTIONS TO COMBAT DRUG RESISTANT GONORRHOEA (#117)

Targetting a key gluconeogenic enzyme as a treatment for Type 2 Diabetes. (#118)

CHARACTERISING THE INFLUENCE OF SNPs ON THE REGULATION OF Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE β (CaMKKβ) (#119)

Matthew T O'Brien

Optimisation of biotin triazoles as new antibiotics targeting Biotin Protein Ligase from Staphylococcus aureus (#120)

Ashleigh S Paparella

Molecular mechanisms of plasminogen activation by bacterial cofactor streptokinase (#121)

Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the START domain (#122)

Crystall Swarbrick

Acyclic nucleoside phosphonates as inhibitors of Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase (#123)

Investigation of a putative proton relay chain in the enzyme 3-deoxy-D-manno-octulosonate 8-phosphate synthase (#124)

Michael A. Weusten

A structural and biophysical analysis of the wheat NOD-like receptor, Sr33. (#126)

Novel approach of characterizing prion-like protein: ASC (#127)

The functional and structural role of cysteine residues in Toll-like receptor signalling adaptor MAL/ TIRAP (#128)

Peter Lavrencic

Structural Recognition of CD1d-restricted Microbial lipid antigen by Type II Natural killer T cells (#129)

Srinivasan Sundararaj

The Structural and Molecular Investigations Into Natural Killer T cell receptor (NKT) and CD1d-Glycolipid Recognition (#130)

Praveena Thirunavukkarasu

HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 (#131)

Expression, purification and crystallization of a phosphoethanolamine transferase from Neisseria (#132)

Anandhi Anandan

Stabilization of human aquaporin 10 for structural determination (#133)

Rebecka Andersson

Using Neutron Diffraction to Further Study Yeast Aquaporin AQY1 (#134)

Complete mapping of the specificity of the SNARE assembly (#135)

Structural and functional characterization of K⁺channels (#136)

PROBING TRANSMEMBRANE STRUCTURE IN THE T CELL RECEPTOR COMPLEX (#137)

Logesvaran Krshnan

The Molecular Basis of the Interaction between Spider Toxins and the Voltage-Sensor Domain of Voltage-Gated Ion Channels (#138)

Ancestral reconstruction and consensus mutagenesis provide insight into the substrate specificity and evolution of the marine algae Δ6-desaturases (#139)

A new model for pore formation by cholesterol-dependent cytolysins (#140)

Intra-membrane Substrate Recognition by Membrane-associated RING-CH E3 Ligases (#141)

Regulation of immune cell-surface protein levels through transmembrane interactions with membrane-associated RING-CH (MARCH) E3 ubiquitin ligases (#142)

Raphael Trenker

Effect of the Lipidic Cubic Phase on Incorporation of Integral Membrane Proteins for In Meso Crystallisation. (#143)

Leonie van 't Hag

Rational Development of Novel Analgesics for the Treatment of Chronic Pain: Structure-Function Studies of an Engineered Na_V1.7 Blocker (#144)

Sporicidal and anti-biofilm activity of PIN and PIN-like peptides (#145)

Understanding the mechanism of Amyloid Formation of Peptide Pharmaceuticals (#146)

Karolina Zapadka

Insights into potency and selectivity determinants for nAChRs from AChBP-LsIA co-crystal structure. (#147)

Epigenetic Silencing of CSK-homologous kinase (CHK) leads to over-activation of oncogenic Src-family kinases in colorectal carcinoma (#148)

Unravelling the Self-Association Mechanism of High Mobility Group Box 1 (HMGB1) and its Interaction with DNA and Receptor of Advanced Glycation End-products (RAGE) (#149)

Wresti Listu Anggayasti

Identifying interacting partners of Bak and Bax using proximity-induced biotinylation (#150)

Jonathan Bernardini

Friend or Foe? Unravelling the allosteric interactions between two enzymes from Mycobacterium tuberculosis (#151)

Nicola J Blackmore

Investigation of BOK, a poorly understood Bcl-2 family protein (#152)

Towards Structural Studies of Pro-Survival Protein Complexes (#153)

Maria-Jose Garcia-Bonete

Elucidating the Disease-Associated Conformation of Human ApoE4 (#155)

Can alternating electric fields affect the kinetics of microtubule polymerization? (#156)

Rajiv Harimoorthy

Towards elucidation of the proton-coupled electron transfer reaction mechanism in manganese superoxide dismutase through disruption of the dimer interface (#157)

Jatnika Hermawan

Uncovering hidden allostery (#158)

Mcl-1 and Bcl-x_L can bind activated Bak to block apoptosis in response to BH3-only protein (#159)

NMR Characterization of Cooperativity: Fast Ligand Binding Coupled to Slow Protein Dimerization (#160)

Inhibition of JAK signalling by SOCS1 (#161)

Towards a structural understanding of the cell polarity regulator and tumour suppressor protein, Scribble (#162)

Structural and functional analysis of copper trafficking pathways in human cells. (#163)

Shadi Maghoolpilehrood

Defining the interactome of transcription factors that control differentiation of lymphatic endothelial cells (#164)

Mehdi Moustaqil

Controlling protein functions with light: New tools for optogenetic bio-applications in vitro and in the cell. (#165)

Protein import to the mitochondrial inner membrane: Towards structure and mechanism (#166)

Agalya Periasamy

Novel FRET-based interaction approaches provide insights into LIM transcription factor complex formation (#167)

Neil O Robertson

Chemokine recognition by the CC chemokine receptor CCR1 (#168)

Dissecting the N-end rule pathway of protein degradation in Mycobacterium smegmatis (#169)

The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication (#170)

Impact of dramatic structural changes of MinE on the patterning of the E. coli Min protein system. (#171)

Structural analysis of Plasmodium falciparum aminopeptidase PfA-M1 (#172)

The TRIM5α RING domain in signalling and retroviral restriction (#173)

Elucidating the molecular details of RssB-mediated turnover of SigmaS by the AAA+ protease, ClpXP and its inhibition by anti-adaptors. (#174)

Jessica E Zammit

Revealing the structural basis of recognition of mitochondrial carrier proteins by the TOM complex (#175)

Alexander W.H. Rey

Identification of putative human mitochondrial APP3m substrates and their turnover by AAA+ proteases (#176)