The Gram-negative cell envelope as seen by protein antibiotics

The Gram-negative cell envelope as seen by protein antibiotics

The Gram-negative cell envelope as seen by protein antibiotics (#39)

Colin Kleanthous ¹

University of Oxford, Oxford, UK, United Kingdom

Protein antibiotics are species-specific antimicrobials deployed by Gram-negative bacteria to kill their neighbours during competition for resources. My laboratory is exploring the import mechanism of nuclease colicins, protein antibiotics that specifically target nucleic acids in the cytoplasm of Escherichia coli. As well as trying to understand how these folded, 60-kDa proteins translocate into bacteria we are also exploiting colicins as molecular probes of fundamental cell envelope processes. My talk will focus on the latter area and in particular some recent work where we have discovered how Gram-negative bacteria organise their outer membrane proteins.

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Kleanthous, C

I obtained my BSc and PhD in Biochemistry at the University of Leicester. Following postdoc positions in Berkeley and Glasgow, I obtained my first academic appointment as a lecturer in the School of Biological Sciences at the University of East Anglia in 1991. I was promoted to professor in 1999. In 2002 I moved to the Department of Biology at the University of York as the professor of Biochemistry. In 2012 I moved to the Department of Biochemistry at the University of Oxford to become the 5th Iveagh chair of Microbial Biochemistry. My most recent external job has been chairman of the Biochemical Society (2011-2013).

The Gram-negative cell envelope as seen by protein antibiotics (#39)

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