Chromodomain Helicase DNA-binding protein 4 (CHD4) is a chromatin-remodeling enzyme that has been reported to regulate DNA-damage responses through its N-terminal region in a poly(ADP)ribose polymerase dependent manner. We have identified and determined the structure of a stable domain in this N-terminal region. The fold consists of a four α-helix bundle with structural similarity to the High Mobility Group (HMG) box, a domain that is well known as a DNA-binding module. We show that the N-terminal domain of CHD4 binds with higher affinity to poly(ADP)ribose (PAR) than to DNA, suggesting that this region could play a role in localizing CHD4 to sites of DNA-damage.