Fluorescence Approaches to Probing Dynamic Processes in Biological Systems

Fluorescence Approaches to Probing Dynamic Processes in Biological Systems

Fluorescence Approaches to Probing Dynamic Processes in Biological Systems (22056)

Yuning Hong ¹

University of Melbourne, Parkville, VIC, Australia

Fluorescence is a powerful technique that could provide spatiotemporal information with exquisite sensitivity. The lifetime of fluorescence emission is in the nanosecond range, which is relatively fast compared to most protein conformational transitions, making fluorescence one of the most suitable methods for the study of dynamic processes of biomolecules. In this presentation, I will introduce how we make use of a combination of advanced fluorescence techniques as well as new fluorescent probes to elucidate conformational dynamics of biomolecules such as cytochrome c-cardiolipin interaction and amyloid protein aggregation. Meanwhile, a series of photostable fluorogens with aggregation-induced emission characteristics will be presented for monitoring and manipulating the morphological dynamics of subcellular organelles.

Authors contributing to this presentation.

Hong, Y

Dr Yuning Hong received her BSc in Chemistry from Sun Yat-sen University in 2006. After graduation, she joined Prof Ben Zhong Tang's group in Hong Kong University of Science & Technology (HKUST) for her doctoral studies and obtained her PhD in 2011. She then worked as a Postdoctoral Research Associate in Dartmouth College in Biophysical Chemistry for one year before returning to HKUST as a Research Assistant Professor of Chemistry and Junior Fellow of Institute for Advanced Study. She recently joined the School of Chemistry, The University of Melbourne as a McKenzie Fellow. Dr Hong is the author and co-author of over 60 scientific papers and inventor of six US patents and patent applications. Her current research interests focus on the development of novel luminescent materials and exploration of their biological applications including (1) recognition of important biological substances, (2) monitoring of conformational change processes of biomolecules, and (3) bio-imaging.

Fluorescence Approaches to Probing Dynamic Processes in Biological Systems (22056)

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