Expanding the physiological roles of the ser-lys cyclic amidases of the Toblerone fold family (#346)
The intensive use of the herbicide atrazine in agriculture has resulted in its accumulation in the environment above permitted limits. The problems associated with its bioaccumulation are well understood, and atrazine has been reported to act as an endocrine disruptor in vertebrates4. In response to this accumulation, bacteria have evolved pathways to utilize atrazine as a nitrogen source. This pathway has been investigated for bioremediation applications, and serves as a model for evolutionary mechanisms.