Expanding the physiological roles of the ser-lys cyclic amidases of the Toblerone fold family — ASN Events

Expanding the physiological roles of the ser-lys cyclic amidases of the Toblerone fold family (#346)

sahil balotra 1 2 , Tom Dr Peat 3 , Janet Dr Newman 3 , Matt Dr Wilding 1 , Santosh Dr Panjikar 4 , Colin Dr Scott 1 , Peter Dr Campbell 1 , Chris Dr Easton 2 , Andrew Dr Warden 1 , Nathan Dr Cowieson 4 , Del Dr lucent 5
  1. CSIRO, Canberra, ACT, Australia
  2. Rsc, ANU, Canberra, ACT, Australia
  3. Manufacturing, CSIRO, Melbourne, Victoria, Australia
  4. Australian synchrotron, Melbourne, Victoria, Australia
  5. Division of Engineering and Physics, Wilkes University, Wilkes-Barre, Pennsylvania, USA

The intensive use of the herbicide atrazine in agriculture has resulted in its accumulation in the environment above permitted limits. The problems associated with its bioaccumulation are well understood, and atrazine has been reported to act as an endocrine disruptor in vertebrates4. In response to this accumulation, bacteria have evolved pathways to utilize atrazine as a nitrogen source. This pathway has been investigated for bioremediation applications, and serves as a model for evolutionary mechanisms.